DIHEXA vs MK-677 (Ibutamoren)
§ 01 — Attributes
DIHEXAPNB-0408
MK-677 (Ibutamoren)Ibutamoren
Summary
An angiotensin IV analogue with neurogenic effects. Widely cited as the most potent cognitive enhancer in the peptide space — users describe "leg day for the mind".
An orally active ghrelin receptor agonist that mimics growth hormone secretagogues without injections. Technically a small molecule, but included because it dominates GH-secretagogue conversations alongside CJC-1295/ipamorelin.
Mechanism
DIHEXA augments hepatocyte growth factor (HGF) / c-Met signalling, driving dendritic spine formation and new synaptic connections in the hippocampus.
MK-677 binds the ghrelin receptor (GHSR-1a), triggering GH and IGF-1 elevation. Unlike peptide secretagogues, it's orally bioavailable.
Typical dose
8–45 mg per week (research protocols)
10–25 mg oral, once daily (usually bedtime)
Half-life
Not well characterised
~24 hours
Administration
Subcutaneous, Topical (transdermal)
Oral
Regulatory status
research-only
research-only
Cheapest in stock
Not yet listed
Not yet listed
Offers tracked
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