Epitalon vs NAD+

A tetrapeptide (Ala-Glu-Asp-Gly) developed in 1980s Soviet research, claimed to activate telomerase and modulate melatonin secretion from the pineal gland.

Not a peptide but a coenzyme. We include it because it's one of the fastest-growing adjacent searches alongside peptides, and longevity-adjacent clinics bundle it with peptide stacks.

Epitalon is proposed to upregulate telomerase activity, potentially slowing telomere shortening in somatic cells. It has also been shown in animal models to restore pineal melatonin rhythm and improve circadian regulation.

NAD+ is a coenzyme central to cellular energy metabolism and sirtuin activation. Supplementation theoretically restores age-declining NAD+ levels, supporting mitochondrial function.

5–10 mg daily for 10–20 days, 1–2 courses per year (traditional protocol)

250–500 mg IV, or 100 mg subcutaneous, or 250–500 mg oral (as precursor)

Not well characterised

Short (hours); precursor loading is the long game

Subcutaneous, Intranasal

IV, Subcutaneous, Oral

research-only

approved

£15 · £1.5/mg via Peptides UK

Not yet listed