Epitalon vs Pinealon

A tetrapeptide (Ala-Glu-Asp-Gly) developed in 1980s Soviet research, claimed to activate telomerase and modulate melatonin secretion from the pineal gland.

A Russian-developed tripeptide (Glu-Asp-Arg) from pineal-gland research. Used for cognitive enhancement, stress regulation, and age-related decline.

Epitalon is proposed to upregulate telomerase activity, potentially slowing telomere shortening in somatic cells. It has also been shown in animal models to restore pineal melatonin rhythm and improve circadian regulation.

Pinealon modulates pineal and hypothalamic-pituitary axis signalling, with reported effects on dopamine, serotonin, and the HPA axis. Part of Khavinson's "bioregulator" class.

5–10 mg daily for 10–20 days, 1–2 courses per year (traditional protocol)

100–300 mcg daily (oral or injectable)

Not well characterised

Short — typically daily dosing

Subcutaneous, Intranasal

Subcutaneous, Oral

research-only

research-only

£15 · £1.5/mg via Peptides UK

Not yet listed