Melanotan II vs GHK-Cu (injectable)

A synthetic analogue of alpha-MSH that stimulates melanin production in the skin, giving a deep tan with minimal sun exposure. Also has side effects on sexual function and appetite.

A naturally occurring copper tripeptide that activates over 4,000 genes involved in tissue remodelling and wound healing. Injectable form is used for systemic repair; topical form dominates cosmetics.

Melanotan II is a non-selective melanocortin receptor agonist (MC1R, MC3R, MC4R, MC5R). MC1R activation drives melanogenesis; MC4R activation is what gives PT-141 its libido effect.

GHK-Cu binds copper ions and enters cells via copper-transport pathways. It modulates expression of genes governing collagen synthesis, angiogenesis, antioxidant defence, and skin-barrier repair.

100 mcg daily loading, 250–500 mcg maintenance

1–3 mg subcutaneous, 3–5x per week

~33 hours

~1 hour (but downstream gene effects persist)

Subcutaneous

Subcutaneous, Topical

research-only

research-only

Not yet listed

£80 · £1.6/mg via My-Peptides