MOTS-c vs Epitalon

A 16-amino-acid mitochondrial-derived peptide encoded within the 12S rRNA gene, with research interest in metabolic regulation, insulin sensitivity, and exercise capacity.

A tetrapeptide (Ala-Glu-Asp-Gly) developed in 1980s Soviet research, claimed to activate telomerase and modulate melatonin secretion from the pineal gland.

MOTS-c moves between mitochondria, cytosol, and nucleus depending on metabolic state. It activates AMPK, improves glucose uptake, and regulates nuclear gene expression related to metabolic homeostasis. Circulating MOTS-c declines with age.

Epitalon is proposed to upregulate telomerase activity, potentially slowing telomere shortening in somatic cells. It has also been shown in animal models to restore pineal melatonin rhythm and improve circadian regulation.

5–10 mg, 1–3 times per week (research protocols)

5–10 mg daily for 10–20 days, 1–2 courses per year (traditional protocol)

~3 hours

Not well characterised

Subcutaneous

Subcutaneous, Intranasal

investigational

research-only

£30 · £3.0/mg via Peptides UK

£15 · £1.5/mg via Peptides UK