MOTS-c vs NAD+

A 16-amino-acid mitochondrial-derived peptide encoded within the 12S rRNA gene, with research interest in metabolic regulation, insulin sensitivity, and exercise capacity.

Not a peptide but a coenzyme. We include it because it's one of the fastest-growing adjacent searches alongside peptides, and longevity-adjacent clinics bundle it with peptide stacks.

MOTS-c moves between mitochondria, cytosol, and nucleus depending on metabolic state. It activates AMPK, improves glucose uptake, and regulates nuclear gene expression related to metabolic homeostasis. Circulating MOTS-c declines with age.

NAD+ is a coenzyme central to cellular energy metabolism and sirtuin activation. Supplementation theoretically restores age-declining NAD+ levels, supporting mitochondrial function.

5–10 mg, 1–3 times per week (research protocols)

250–500 mg IV, or 100 mg subcutaneous, or 250–500 mg oral (as precursor)

~3 hours

Short (hours); precursor loading is the long game

Subcutaneous

IV, Subcutaneous, Oral

investigational

approved

£30 · £3.0/mg via Peptides UK

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