Semax vs MK-677 (Ibutamoren)
§ 01 — Attributes
SemaxMEHFPGP
MK-677 (Ibutamoren)Ibutamoren
Summary
A Russian-developed short neuropeptide derived from ACTH, used clinically in Russia for stroke and cognitive deficits. Popular among biohackers for focus and stress resilience.
An orally active ghrelin receptor agonist that mimics growth hormone secretagogues without injections. Technically a small molecule, but included because it dominates GH-secretagogue conversations alongside CJC-1295/ipamorelin.
Mechanism
Semax modulates dopamine and serotonin systems, upregulates BDNF, and has neuroprotective effects. Administered intranasally for direct CNS penetration.
MK-677 binds the ghrelin receptor (GHSR-1a), triggering GH and IGF-1 elevation. Unlike peptide secretagogues, it's orally bioavailable.
Typical dose
250–1000 mcg intranasal, 1–2x per day
10–25 mg oral, once daily (usually bedtime)
Half-life
Short (hours) — but effects compound over 2–4 weeks
~24 hours
Administration
Intranasal
Oral
Regulatory status
research-only
research-only
Cheapest in stock
£16 · £3.2/mg via Peptides UK
Not yet listed
Offers tracked
1
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