Sermorelin vs Ipamorelin

An FDA-approved growth-hormone-releasing hormone (GHRH) analogue that stimulates the pituitary to release natural GH. Staple of anti-aging clinics and the gateway GH secretagogue.

A selective growth hormone secretagogue that stimulates pulsatile GH release from the pituitary without significantly affecting cortisol, prolactin, or appetite.

Sermorelin is the first 29 amino acids of endogenous GHRH — enough to bind the pituitary GHRH receptor and trigger physiological GH pulses. Unlike exogenous HGH, endogenous feedback loops remain intact.

Ipamorelin binds the ghrelin receptor (GHSR-1a) in the pituitary, triggering growth hormone release. Unlike earlier secretagogues such as GHRP-6, ipamorelin is highly selective and does not induce hunger or stimulate cortisol.

200–500 mcg subcutaneous at bedtime

200–300 mcg, 1–3 times daily (research protocols)

~11–12 minutes

~2 hours

Subcutaneous

Subcutaneous

approved

research-only

Not yet listed

£21 · £4.2/mg via Peptides UK