Orforglipron half-life
How long Orforglipron stays active in the body, what that means for your dosing schedule, and where to buy.
Orforglipron half-life
~25 hours
Typical dose
12–36 mg oral once daily (in trials)
What half-life means for Orforglipron
Half-life is the time it takes for half the compound to be cleared from the body. Shorter half-lives (< 4h) usually require daily or multiple-daily dosing to maintain levels; longer half-lives (days) support once-weekly protocols.
For Orforglipron, the characterised half-life is ~25 hours. This directly informs the typical protocol of 12–36 mg oral once daily (in trials).
Full mechanism, benefits, and dosing guidance on the main Orforglipron page.