Semaglutide half-life
How long Semaglutide stays active in the body, what that means for your dosing schedule, and where to buy.
Semaglutide half-life
~7 days
Typical dose
0.25 mg weekly, titrated up to 2.4 mg weekly for weight loss
What half-life means for Semaglutide
Half-life is the time it takes for half the compound to be cleared from the body. Shorter half-lives (< 4h) usually require daily or multiple-daily dosing to maintain levels; longer half-lives (days) support once-weekly protocols.
For Semaglutide, the characterised half-life is ~7 days. This directly informs the typical protocol of 0.25 mg weekly, titrated up to 2.4 mg weekly for weight loss.
Full mechanism, benefits, and dosing guidance on the main Semaglutide page.