Tirzepatide half-life
How long Tirzepatide stays active in the body, what that means for your dosing schedule, and where to buy.
Tirzepatide half-life
~5 days
Typical dose
2.5 mg weekly, titrated up to 15 mg weekly
What half-life means for Tirzepatide
Half-life is the time it takes for half the compound to be cleared from the body. Shorter half-lives (< 4h) usually require daily or multiple-daily dosing to maintain levels; longer half-lives (days) support once-weekly protocols.
For Tirzepatide, the characterised half-life is ~5 days. This directly informs the typical protocol of 2.5 mg weekly, titrated up to 15 mg weekly.
Full mechanism, benefits, and dosing guidance on the main Tirzepatide page.