The BowTiedHRT Fun/Effectiveness Rated Stack
A mixed performance-and-wellness stack from an HRT-focused X operator who rates every compound on Fun (FR) and Effectiveness (ER) scales out of 10.
Source post ↗The FR/ER method
BowTiedHRT rates every compound on two scales — Fun and Effectiveness — out of 10. Some of the most useful compounds (HGH, FR 2 / ER 10) are deeply unfun; some fun ones (DIHEXA, FR 10 / ER 10) are genuinely cognition-changing.
The stack
- Tirzepatide 2 mg/week — food-noise reduction, trouble-free. FR 5, ER 8.
- Retatrutide — "king of GLP sphere", but titrate slowly. FR 3, ER 9.
- DIHEXA 10 mg 2x/week — "leg day for the mind". FR 10, ER 10.
- Melanotan II 100 mcg daily loading — summer tan secured. FR 9, ER 8.
Why we picked this
Honest, lived experience with direct dose guidance. The FR/ER ratings are a format we're rolling out across every peptide page on Pepwizard — this stack is the original source.
The compounds in this stack
Tirzepatide
A dual GIP and GLP-1 receptor agonist producing the largest sustained weight reductions of any drug currently licensed, averaging 20–22% body weight loss in clinical trials.
Retatrutide
A triple agonist of GIP, GLP-1, and glucagon receptors in late-stage clinical trials, producing ~24% weight loss at 48 weeks in Phase 2 — the largest effect size of any weight-loss pharmaceutical to date.
DIHEXA
An angiotensin IV analogue with neurogenic effects. Widely cited as the most potent cognitive enhancer in the peptide space — users describe "leg day for the mind".
Melanotan II
A synthetic analogue of alpha-MSH that stimulates melanin production in the skin, giving a deep tan with minimal sun exposure. Also has side effects on sexual function and appetite.