The Nass Eddequiouaq Fat-Loss Stack
28 lbs lost in 22 days on retatrutide plus a targeted follow-on stack — documented live on X.
Source post ↗The protocol
Nass shared the raw numbers publicly: 28 lbs lost in 22 days on retatrutide 2mg/week alongside a protein-first diet, no alcohol, and two daily workouts. His follow-on stack is built to preserve lean mass and target the depots retatrutide alone won't.
The add-ons
- Tesamorelin — visceral fat reduction (the depot GLP-1s don't selectively target).
- MOTS-c — mitochondrial/metabolic health.
- 5-Amino-1MQ — fat-storage reduction via NNMT inhibition.
Caveats
This is an aggressive rate of loss. Pair with comprehensive blood work, electrolyte support, and lean-protein intake ≥1.6 g/kg. Do not replicate without clinician oversight.
The compounds in this stack
Retatrutide
A triple agonist of GIP, GLP-1, and glucagon receptors in late-stage clinical trials, producing ~24% weight loss at 48 weeks in Phase 2 — the largest effect size of any weight-loss pharmaceutical to date.
Tesamorelin
An FDA-approved growth-hormone-releasing hormone analogue for HIV-associated lipodystrophy, used off-label for visceral fat reduction and metabolic health.
MOTS-c
A 16-amino-acid mitochondrial-derived peptide encoded within the 12S rRNA gene, with research interest in metabolic regulation, insulin sensitivity, and exercise capacity.
5-Amino-1MQ
A first-in-class NNMT (nicotinamide N-methyltransferase) inhibitor that redirects cellular energy toward metabolic acceleration. Early clinical pipeline; widely used in biohacker fat-loss protocols.