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Longevity Starter Stack
A conservative entry-point longevity stack — GH secretagogue pairing for body composition and sleep, plus MOTS-c for mitochondrial/metabolic support.
- Duration
- 12 weeks per cycle
- Experience
- intermediate
Peptides in this stack
CJC-1295
A synthetic GHRH analogue that stimulates pituitary growth hormone release. The short-acting form (no DAC) is typically paired with a ghrelin agonist like ipamorelin.
Ipamorelin
A selective growth hormone secretagogue that stimulates pulsatile GH release from the pituitary without significantly affecting cortisol, prolactin, or appetite.
MOTS-c
A 16-amino-acid mitochondrial-derived peptide encoded within the 12S rRNA gene, with research interest in metabolic regulation, insulin sensitivity, and exercise capacity.
Rationale
No peptide extends human lifespan in rigorous evidence. What peptides can plausibly do is preserve lean mass, metabolic flexibility, and sleep architecture — the mechanisms underlying much of age-related decline.
This starter stack pairs a pulsatile GH secretagogue combination (CJC-1295 no DAC + ipamorelin) with MOTS-c for mitochondrial/metabolic benefits. It avoids the more speculative compounds in the longevity category.
Sample protocol
| Peptide | Dose | Timing |
|---|---|---|
| CJC-1295 (no DAC) | 100 mcg | Pre-bed, fasted |
| Ipamorelin | 200 mcg | Pre-bed, fasted (same injection) |
| MOTS-c | 5 mg | Once weekly, morning |
12-week cycles with 4-week off-periods are a common approach to minimise any tolerance development and allow endogenous function to maintain itself.
What this is not
- Not a substitute for exercise, sleep, or diet — these remain the largest known levers on healthspan.
- Not appropriate for anyone with active or previously treated cancer (GH pathway interactions).
- Not a telomere-extension protocol (see epitalon for caveats).
Considerations
- Blood glucose and HbA1c should be monitored — GH elevation can transiently impair insulin sensitivity.
- IGF-1 baseline can be checked before and after a cycle to track response.
- Skip MOTS-c if you are lean, insulin-sensitive, and metabolically well — most of the preclinical benefit is in the context of metabolic dysfunction.