28 lbs lost in 22 days on retatrutide — what people get wrong about the 'king of GLP-1'
“Nass Eddequiouaq lost 28 lbs in 22 days on retatrutide 2 mg/week. The viral post hides the less-comfortable reality of this compound.”
The viral number
Nass Eddequiouaq posted it live: 28 lbs in 22 days on retatrutide 2 mg/week, plus a protein-heavy diet, no alcohol, and two daily workouts. X ate it.
Why retatrutide works
Retatrutide hits three receptors: GIP, GLP-1, and glucagon. The glucagon agonism is the new trick — it increases energy expenditure on top of the appetite suppression you get from GLP-1 activity. In Phase 3 trials it produced up to 28.7% weight loss, substantially more than tirzepatide or semaglutide.
What the viral posts skip
Retatrutide is unforgiving. BowTiedHRT called 2 mg "WAY too much" starting out. At that dose, some users report:
- Full anhedonia — joy pathways flattened for days.
- Libido torpedoed.
- Nausea that doesn't respond to Zofran.
- Muscle loss if protein intake isn't ≥1.6 g/kg.
The correct starting dose for most people is 0.5 mg/week, titrated up over 8–12 weeks.
The stack Nass is planning next
After the initial cut, Nass is adding:
- Tesamorelin for visceral fat.
- MOTS-c for mitochondrial support.
- 5-Amino-1MQ for NNMT inhibition.
Full breakdown on our Nass Eddequiouaq stack page.
Where to buy
Retatrutide is pre-approval in every major market. Research-chemical vendors sell it; provenance is uneven. See our retatrutide price comparison for the vendors we've independently vetted.